
CX-6258 HCl
CAS No. 1353859-00-3
CX-6258 HCl ( CX-6258 Hydrochloride | CX 6258 Hydrochloride )
产品货号. M17253 CAS No. 1353859-00-3
CX-6258 HCl 是一种有效的口服 Pim1/2/3 激酶抑制剂 (IC50: 5/25/16 nM)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥413 | 有现货 |
![]() ![]() |
5MG | ¥648 | 有现货 |
![]() ![]() |
10MG | ¥1191 | 有现货 |
![]() ![]() |
25MG | ¥2163 | 有现货 |
![]() ![]() |
50MG | ¥3621 | 有现货 |
![]() ![]() |
100MG | ¥5208 | 有现货 |
![]() ![]() |
500MG | ¥10773 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称CX-6258 HCl
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述CX-6258 HCl 是一种有效的口服 Pim1/2/3 激酶抑制剂 (IC50: 5/25/16 nM)。
-
产品描述CX-6258 HCl is a potent, selective, and orally efficacious pan-Pim kinases inhibitor.
-
体外实验Western Blot Analysis Cell Line:MV-4-11 human AML cells.Concentration:0.1 μM, 1 μM, 10 μM.Incubation Time:2 hours.Result:Caused dose dependent inhibition of the phosphorylation of two pro-survival proteins, Bad and 4E-BP1, at the Pim kinase specific sites S112 and S65 and T37/46, respectively.
-
体内实验Animal Model:Nude mice, MV-4-11 xenograft modelsDosage:50 mg/kg, 100 mg/kg.Administration:Oral administration; once daily; over a period of 21 days.Result:Exhibitd dose dependent efficacy, with a 50 mg/kg dose producing 45% tumor growth inhibition (TGI) and a 100 mg/kg dose producing 75% TGI.
-
同义词CX-6258 Hydrochloride | CX 6258 Hydrochloride
-
通路Others
-
靶点Other Targets
-
受体Pim1| Pim2| Pim3
-
研究领域Cancer
-
适应症——
化学信息
-
CAS Number1353859-00-3
-
分子量498.4
-
分子式C26H24ClN3O3·HCl
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 10 mg/mL (20.06 mM)
-
SMILESCN1CCCN(CC1)C(=O)c1cccc(c1)c1ccc(o1)/C=C/1\c2c(ccc(c2)Cl)NC1=O.Cl
-
化学全称(3E)-5-Chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-indol-2-one hydrochloride
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Haddach M, et al. ACS Medicinal Chemistry Letters, 3 (2) , 135-139
产品手册




关联产品
-
Lilial
Lilial(百合醛的商品名,也称为铃兰醛)是一种化合物,通常在化妆品制剂和洗衣粉中用作香料,通常名称为丁基苯基甲基丙醛。
-
2,3-Dehydrokievitone
2,3- Dehydrokievitone exhibits strong cytotoxic activity and induces apoptosis efficiently in cancer cells.
-
2-(7-Methoxy-1-napht...
2-(7-甲氧基-1-萘基)乙胺盐酸盐是抗抑郁药阿戈美拉汀的杂质。