
CX-6258 HCl
CAS No. 1353859-00-3
CX-6258 HCl ( CX-6258 Hydrochloride | CX 6258 Hydrochloride )
产品货号. M17253 CAS No. 1353859-00-3
CX-6258 HCl 是一种有效的口服 Pim1/2/3 激酶抑制剂 (IC50: 5/25/16 nM)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥413 | 有现货 |
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5MG | ¥648 | 有现货 |
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10MG | ¥1191 | 有现货 |
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25MG | ¥2163 | 有现货 |
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50MG | ¥3621 | 有现货 |
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100MG | ¥5208 | 有现货 |
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500MG | ¥10773 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称CX-6258 HCl
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述CX-6258 HCl 是一种有效的口服 Pim1/2/3 激酶抑制剂 (IC50: 5/25/16 nM)。
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产品描述CX-6258 HCl is a potent, selective, and orally efficacious pan-Pim kinases inhibitor.
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体外实验Western Blot Analysis Cell Line:MV-4-11 human AML cells.Concentration:0.1 μM, 1 μM, 10 μM.Incubation Time:2 hours.Result:Caused dose dependent inhibition of the phosphorylation of two pro-survival proteins, Bad and 4E-BP1, at the Pim kinase specific sites S112 and S65 and T37/46, respectively.
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体内实验Animal Model:Nude mice, MV-4-11 xenograft modelsDosage:50 mg/kg, 100 mg/kg.Administration:Oral administration; once daily; over a period of 21 days.Result:Exhibitd dose dependent efficacy, with a 50 mg/kg dose producing 45% tumor growth inhibition (TGI) and a 100 mg/kg dose producing 75% TGI.
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同义词CX-6258 Hydrochloride | CX 6258 Hydrochloride
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通路Others
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靶点Other Targets
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受体Pim1| Pim2| Pim3
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研究领域Cancer
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适应症——
化学信息
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CAS Number1353859-00-3
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分子量498.4
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分子式C26H24ClN3O3·HCl
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 10 mg/mL (20.06 mM)
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SMILESCN1CCCN(CC1)C(=O)c1cccc(c1)c1ccc(o1)/C=C/1\c2c(ccc(c2)Cl)NC1=O.Cl
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化学全称(3E)-5-Chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-indol-2-one hydrochloride
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Haddach M, et al. ACS Medicinal Chemistry Letters, 3 (2) , 135-139
产品手册




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